Bad Obstetric History (BOH) Test - Book at an Affordable Cost

When there have been two or more consecutive spontaneous abortions, early neonatal deaths, stillbirths, intrauterine fetal deaths, intrauterine growth retardation, or congenital malformations, there has likely been an adverse fetal result in the past. Consequently, for such obstetric patients, modern laboratories provide BOH profiles. For medical professionals to assess the potential reason and assist patients with BOH, the profile includes a battery of tests.

• Maternal infection, aberrant maternal immune response, and genetic and hormonal factors can all contribute to BOH pathogenesis. Immune-related factors have a significant impact on how pregnancies turn out, and certain antibodies have been discovered as biomarkers for BOH patients. Both autoimmune and alloimmune variables could apply to them. This profile contains results from many of these antibody tests. BOH is also frequently brought on by primary infections brought on by TORCH—Toxoplasma gondii, rubella virus, cytomegalovirus (CMV), and Herpes simplex virus (HSV)—which is another important cause.

Test comprised

• ANA
• TSH
• TORCH
• ACL - IgG, IgM 
• APA - IgG, IgM 
• Lupus Anti
• ANA

Anti-phospholipid antibodies and anti-thyroid antibodies are two more autoimmune variables that include anti-nuclear antibodies, or ANA. Raised levels of autoimmune antibodies may be present in women who have a history of problems during pregnancy without having an autoimmune illness. Pre-eclampsia, intrauterine growth restriction, fetal mortality, and placental abruption have all been linked to anti-nuclear antibodies. According to studies, antinuclear antibodies may obstruct the development and maturation of the placenta, which would ultimately result in an early miscarriage.

• ACL-IgG and IgM

Anticardiolipin (ACL or aCL) antibodies (IgG & IgM) are a subset of autoimmune antibodies known as anti-phospholipid antibodies. According to a study, women with three or more recurrent miscarriages have higher quantities of ACL antibodies in their systems. Testing ACL levels can therefore lower patient mortality in BOH cases.

IgG and IgM APA

Antiphospholipid antibodies (APA), which attach to negatively charged phospholipids, are autoimmune antibodies. Elevated APA levels result in thrombotic events that put the mother's and the baby's health at risk, eventually leading to miscarriage and complications therefrom.

Anticardiolipin, antinuclear, and lupus antibodies. Lupus Anticoagulant (LA), is strongly linked to recurrent miscarriages that occur before the 24th week of gestation. Due to the incomplete concordance between ACL and LA, which is reported to predict fetal loss, both must be evaluated if antiphospholipid syndrome is suspected.

TSH: The synthesis of thyroxin (T4), tri-iodothyronine (T3), and the need for iodine rise by around 50% during pregnancy, among other physiological alterations to thyroid gland function. Untreated maternal thyroid dysfunction increases the chance of miscarriage and increases the likelihood of fetal hypertension, intrauterine growth retardation, preterm delivery, and worse IQ scores for the offspring. Throughout pregnancy, the test's real results change depending on the trimester. Evaluation of TSH value is essential for treating thyroid dysfunction, a common condition that can become life-threatening in patients with BOH.

TORCH - 8: Preterm labor, early neonatal death, congenital deformity, recurrent abortion, intrauterine growth retardation, and intrauterine death are all linked to TORCH infections. Infection in the mother can become more severe due to the virulence, which can also harm the fetus. It is advised to perform a serological examination for TORCH infection during pregnancy to enable early diagnosis and more effective management of BOH cases.