BCL2 (18q21.3) Gene Rearrangement Test Cost & Procedure

What causes BCL2 to be overexpressed?

When other survival signals are blocked, the overexpression of BCL2 proteins may lower the threshold level of proapoptotic signaling needed to start apoptosis and stop it from happening. This hypothesis could account for our observation that BCL2's protective impact and expression level are correlated.

BCL2 positivity: What does it mean?

Patients in the ABC subgroups who tested positive for BCL2 protein also had greater levels of lactate dehydrogenase and advanced illness stages, both of which are considered to be poor prognostic indicators. 35. In the ABC subgroup but not the GCB subgroup, BCL2 expression could be a biomarker of more severe illness.

In lymphoma, which cells are cancerous?

The most typical kind of blood cancer is lymphoma. Notably, the white blood cell subtype lymphocytes are impacted by lymphoma, a malignancy. To protect the body from external intruders like germs and viruses, lymphocytes move through the blood and lymphatic system.

How does lymphoma cause by BCL2 overexpression develop?

BCL2 protein overexpression is thought to be primarily caused by translocation (14;18)(q32;q21), which is seen in 20–30% of diffuse large B-cell lymphomas (DLBCL). Yet, BCL2 overexpression is frequently found in lymphomas without BCL2 rearrangement, suggesting that t(14;18) is not always the origin of this phenomenon.

What role does the BCL2 gene play?

A protein that controls whether a cell survives or perishes by preventing an apoptotic cell death process. The BCL2 gene is located on chromosome 18, and numerous B-cell leukemias and lymphomas exhibit the transfer of the BCL2 gene to another chromosome.

Is BCL2 an oncogene or a tumor suppressor?

By choosing and preserving long-lived cells and arresting cells in the G0 phase of the cell cycle, overexpression of the protein in cancer cells may prevent or postpone the beginning of apoptosis.

How can BCL2 overexpression cause the progression of a tumor?

The direct binding of Bcl-2 to COX Va is assumed to be the mechanism by which these effects of Bcl-2 overexpression are mediated [60]. As a result, Bcl-2's targeting of COX probably promotes cancer cell invasion and metastasis.

BCL-2 in leukemia: what is it?

Proteins from the B cell lymphoma 2 (BCL-2) family are crucial for intrinsic apoptosis. In acute myeloid leukemia, overexpression of BCL-2 proteins can get around the disease's resistance to treatment and apoptosis.

BCL2 encourages cell death, right?

That is, rather than speeding up cell division, BCL-2 increases the overall number of cells by avoiding cell death.