The Rheumatoid Arthritis can be characterized by a number of factors, an elevated Anti-CCP antibodies or Anti–cyclic Citrullinated peptide act as markers for diagnosis of this Rheumatoid Arthritis Disease.
So, why put your mobility to rest? While, Arthritis has the power to slower our lives and make it painful, there are some tests that can make your life at ease.
What are CCP antibodies?
The CCP antibodies (Cyclic Citrullinated Peptide Antibody) are found in the bloodstream. These demonstrate the antibodies that would fight as a part of the immune system and protect you from the viruses and bacteria.
These prevent you from certain viruses, bacteria etc. However, auto antibodies can cause disease by attacking the body's healthy cells by mistake.
These antibodies are in general found in about 60% to 70% of the people who suffer from Rheumatoid Arthritis (RA).
Apart from the arthritis (joint inflammation) we are aware of: In addition to this, there are autoimmune varieties for example- Rheumatoid Arthritis Or Lupus, there are also cases of this arthritis due to the aging (“normal” wear and tear), the gout, and certain fractures or the infections that could be (viruses, bacteria or fungi).
Detection of the anti-CCP antibodies also confirm presence of your rheumatoid arthritis which is responsible for establishing a prognosis for disease progression and helps determine your best possible treatment.
Other Names: Cyclic Citrullinated Peptide Antibody, Anticitrullinated Peptide Antibody, Citrulline Antibody, Anti-Cyclic Citrullinated Peptide, Anti-CCP Antibody, ACPA
Key Facts about Cyclic Citrullinated Peptide
Value in Healthy People: Anti-CCP occurs in 1.5% or less of healthy populations and in 10% or less of those with other rheumatic disease, except palindromic rheumatism, in which the occurrence is similar to RA.
Natural CCP Reduction: By inhibiting hyperactive immune cells that assault the body's own proteins and tissues, vitamin D may help reduce anti-CCP antibodies Elevated anti-CCP antibodies and rheumatoid arthritis are associated with vitamin D insufficiency.
RA Factor with Anti-CCP: When the patient has positive anti-CCP test along with positive rheumatoid factor test, they would most likely be having the RA test. With about 96% specificity, anti-CCP test will accurately identify the patients that do not have anti-CCP.
Why do you need a CCP antibody Test?
The individuals having symptoms of the rheumatoid arthritis should get this antibody test. The symptoms seen in the condition include:
- Joint Pain
- Joint Swelling
- Joint Stiffness
- Fatigue
- Fever ( Low- Grade)
- Nodules (Under the Skin in Elbows)
You may also need this test if other tests couldn't confirm or rule out a diagnosis of Rheumatoid Arthritis.
Note: While the information is typically correct, there can be variations in the percentage of individuals with ACPAs in RA. It is imperative to seek the advice of a healthcare practitioner for a thorough explanation of test results and their implications.
Other Conditions that Test Positive for Anti-CCP Test
Anti-Cyclic Citrullinated Peptide, or anti-CCP, is a commonly used marker, especially for the condition and disease of rheumatoid arthritis (RA).
It could also be positive for other conditions that also cause arthritis, these include the following:
- Psoriatic Arthritis
- Familial Mediterranean Fever
- Systemic Lupus Erythematosus
- Behçet's Illness
Guidelines to follow before, during and after the Anti-CCP Test Blood Test
Here are some guidelines an individual can refer to once they have decided to undergo CC protein ( Antibody Test)
The required documents needed for this test includes your valid government ID and an appropriate Doctor’s prescription.
A. Before the test
- Nothing Specific to prepare for Anti-CCP in advance.
- Usually, Fasting is not required before the test procedure.
B. During the Test
- During the blood test, the doctor would take the blood sample from the vein in your arm, using the small needle.
- Then, a small amount of blood would be drawn and collected into the corresponding test tube or the vial.
- You might feel a little sting when the needle pricks or while it is being removed. This would usually take less than even five minutes.
C. After the Test
There would be slight tenderness at the injection site without any major concern. This patient is expected to get back to their daily life immediately.
Note: You can still test NEGATIVE for the anti-CCP levels and have RA, especially if you see symptoms in patients
Why Ganesh diagnostic and Imaging Centre should be your preference to for Anti-CCP Test?
Ganesh Diagnostic and Imaging Centre has a long history of offering its patients exceptional service and attention. Years' worth of happy patients in thousands!
Since 2001, it has grown to be a recognized and well-established diagnostic facility.
Their excellence is backed by NABH and NABL Accreditations.
NABH accreditation is proof of highest standard of care and service provided to the patients. NABL accreditation reflects the competency of laboratories and equipment based on some national and international standards.
Test report is available digitally too.
Ganesh Diagnostic and Imaging Centre is a one-stop solution for getting all kinds of tests done, as all services are available under one roof.
The aim of GDIC is to provide world’s finest technology at the lowest price and Free Home Sample Collection Facility
The rates of scans are reasonably priced. Ganesh Diagnostic and Imaging Centre also offer FLAT 50% OFF on many tests.
We also provide - Free Home Sample Collection, Free Ambulance Service an d Free Consultation from the Doctor itself.
Some of the Tests Conducted at Ganesh Diagnostic are as follows:
What is the Anti-CCP Normal Range and Value?
The natural physiological process in the body is citrullination (When the body’s cells die). The Genetics could influence an individual's production of citrulline at different amounts. Enzyme units per milliliter, or EU/ml, are used to measure the Anti-CCP test findings.
Anti Cyclic Citrullinated Peptide Antibody Test Reference Range
Test result for anti-CCP (EU/ml)
- Not more than 20 - Negative (Average)
- 20–39- Only Mildly Positive
- 40–59- Positive but Not Very
- Over 60- Extremely Positive
Positive Value of Anti-CCP Test
The test is known to have a positive value in an asymptomatic person; it would indicate higher chance of rheumatoid arthritis (RA) in the future. On the other hand, a patient with RA who has a high positive test may be at a higher risk of developing an erosive, more severe version of the disease. It's crucial to remember, nevertheless, that an ACCP test by itself is not a conclusive diagnostic tool; a healthcare provider's clinical examination is necessary for an appropriate assessment and diagnosis.
How to Monitor Your Disease with Anti-CCP Test
Inflammation Marker
The Anti-CCP shows the aggressive form of the disease than the people who would not be testing positive for this disease or even for those who would only be testing positive for the condition of Rheumatoid Factor (RA Factor)
A dip in the anti-CCP levels would let the doctors know if the body can have its processes slowed down in the production of those inflammatory auto antibodies, or if the patient with a low disease activity
Frequently Asked Questions (FAQs)
What does Anti-CCP 500 mean?
For instance, an individual with value of 500 anti-CCP antibodies is not 10 times less immune than one with number of 50. This could be safe to conclude, even though, high number of it would correspond to momentum of your Rheumatic Disease rather than the severity.
Can CCP levels change?
There have been multiple studies that showed that the anti-CCP levels might change during the RA course, regardless of any biological drug that is used in having a clinical response.
Does anti-CCP decrease after treatment?
The Serum concentrations of the anti- CCP antibodies are seen to decrease significantly after 6 months of therapy (p < 0.01).
What if anti-CCP is less than 7?
Normal level of the anti-CCP antibodies is then considered to be less than 20 units/mL. Anything, which is over this level mean when you test positive for its antibodies, and any value below that level would indicate a test negative.
Which food items are worst for Arthritis?
5 Foods to Steer Clear of if You Have Arthritis
- Sugar Additions Refined and added sugars aren't just found in cookies and other sweets.
- Trans and Saturated Fats. Trans fats should be minimized in your diet, according to the Arthritis Foundation.
- Alcohol
- Salt
Which Food Items are good for Arthritis?
6 Foods to Consume if you Suffer from Arthritis
- Green Vegetables such as: Broccoli, Cabbage Brussels, Cauliflower, as these items contain the compound sulforaphane
- Fish
- Turmeric
- Vitamin C Food Items
- Garlic
- Cherries
