The Adenosine Deaminase or the ADA is an enzyme that is present in the body. The main function of ADA is to aid in the purine metabolism. It aids in breakdown of adenosine from the food and it thereby also helps in...
What Is Adenosine Deaminase Or ADA?
The Adenosine Deaminase or the ADA is an enzyme that is present in the body. The main function of ADA is to aid in the purine metabolism. It aids in breakdown of adenosine from the food and it thereby also helps in facilitating the turnover of the nucleic acids in the different body tissues.
In humans, the main function of this ADA test or Adenosine Deaminase test would be to keep the immunity developed and well maintained. It is involved in other minute functions as well.
For example:
- Gestation period maintenance
- Subsequent release of the amino acids in the body
- Neurotransmission
- Epithelial cell differentiation
It is measured in the following body fluids, for example: serum, sputum, pleural effusions, and synovial effusions.
What Is ADA Lab Test or Adenosine Deaminase Test?
The ADA Test or Adenosine Deaminase test is usually carried out to detect level of ADA or Adenosine Deaminase in the body’s pleural fluid. The standard objective of this test is mainly for diagnosing Mycobacterium tuberculosis, known as tuberculosis or TB. However, in rare circumstances, it can be done to detect other infections.
What Are Symptoms of Low ADA levels
The symptoms associated with low ADA levels are as follows:
- Pneumonia
- Excessive, frequent diarrhea
- Widespread skin rashes
- Night Sweats
- Fever accompanied by chills
- Sudden weight loss
- Chronic cough
- Prolonged pain in the test
- Developmental delay in children
Guidelines To Follow Before, During and After the Test
Here are some guidelines an individual can refer to once they have decided to undergo ADA test.
The required documents needed for this test includes your valid government ID and an appropriate Doctor’s prescription.
Before the test
Fasting is not required before taking this test.
During the Test
Method: ADA test involves the collection pleural fluid from the pleural cavity of chest.
- This procedure involves the insertion of the needle in between pleural membranes which surround the chest and the lungs.
- The aspirate is then drained through the tube.
- The fluid thus collected would then be sent to the lab for the immunoassay process.
A prick may be felt when needle puncture is made under the skin, to collect the blood sample.
After the test
The adverse effects post the test may include the following:
- Pain at the injection site
- Fever
- Breathing difficulties
- Chest pain
Result Interpretation
In case the individuals Adenosine Deaminase level in the pleural fluid is quite higher than the ADA normal range, the result would usually be indicative of the Mycobacterium tuberculosis infection in the patient.
Other abnormalities also cause the higher levels (mildly or moderately high) of ADA. These are as follows:
- Sarcoidosis
- Pulmonary Embolus
- Cancer or Lupus
These, however, are seen only when the ADA level is mildly or moderately high.
Low levels: If ADA level is low, mostly the patient does not have tuberculosis, but this may not completely rule out TB.
What is the ADA Test Price in Delhi?
Ganesh Diagnostic and Imaging Centre is a one-stop solution for getting all kinds of tests done, as all services are available under one roof.
The aim of GDIC is to provide world’s finest technology at the lowest price.
The rates of scans are reasonably priced. Ganesh Diagnostic and Imaging Centre also offers FLAT 50% OFF on many tests.
Patients can rely upon test reports as reports are 100% accurate Test/Digital Reports.
Irrespective of cost, get the done at the certified diagnostic centre where tests are performed without quality compromise with 100% accuracy.
The ADA price varies by region and facility. So constantly get tested at trustworthy diagnostic centers like Ganesh Diagnostic. It is staffed by trained and experienced professionals to assure patient and visitor safety.
FAQs on ADA Test
How is ADA Deficiency Diagnosed?
The ADA deficiency is mostly detected through the WBC counts and further analysis of various immunoglobulin levels in the T-cells, the B-cells, and other natural killer cells of body’s immune system.
The Biochemical genetic tests have established appropriate diagnosis of the ADA deficiency. There are biochemical tests carried out, which when analyzed show decreased ADA activity, say less than 1% while increased level of the other dATP metabolites for example, dAMP, dADP, and dATP in the RBC-erythrocytes.
This genetic analysis of this probable mutation in the ADA genes would confirm the disease.
How Should You Prepare for the ADA Test? Is Fasting Required?
- In general, there are no specific rules for the preparation of an ADA test. Fasting is also not necessary before undergoing the test.
- However, if consume any medication, you should inform the healthcare professional, as certain chemicals, for example: blood thinners, might interfere with this test.
- Moreover, it is advised to always bring someone to accompany you back home, as there might be a dizzy feeling post- anesthesia use during the test.
Is ADA medical test specific for tuberculosis?
Most studies suggest that ADA test accounts for an early diagnosis of tuberculosis in concurrence with AFB smear test, which is used to identify the existence of the acid-fast bacteria in a patient’s body sample.
What is accuracy in ADA test? What is its Diagnostic Value?
Usually, the serum ADA levels are considered to be 92.7% sensitive and also 88.1% specific in pulmonary TB patients.
That means it allows for detection of ADA at even very low levels in blood.
However, you should compare levels with different tests to be able to distinguish between the TB and the other pulmonary infections.
What is the ADA Normal Range?
The standard range of the Adenosine Deaminase test in both males and the females regardless of their age is known to be 40 units/L.
The Test results which demonstrate the higher values are considered to be abnormal and indicate the following:
- Pleural tuberculosis or Tubercular ascites
- Synovitis, which is caused by rheumatoid arthritis
- Meningitis of tuberculosis in patients
- Lymphadenitis of tuberculosis in patients
- Pneumonia associated with tuberculosis in patients
Understanding the Test Results of the Adenosine Deaminase Test
The ADA activity which is usually higher than the 43U/ml in pleural fluids of the patient normally indicate the pleural tuberculosis with around 81- 100% sensitivity and also above 83% specificity, as stated above.
Moreover, the Higher ADA values might be caused by the underlying health conditions. These are as follows:
- Pulmonary embolism
- Lupus
- Lymphomas
- Sarcoidosis
- Other parapneumonic and vascular diseases
Note: In these cases as mentioned above, the ADA values are higher, but only slightly higher.
Where should I get ADA Test done?
Visit the Nearest Ganesh diagnostic and Imaging Centre
At Ganesh Diagnostic and Imaging Centre, we are known for providing excellent service and care to its patients for decades. Lakhs of satisfied patients over the years!
It is an established and renowned diagnostic centre since 2001.
Their excellence is backed by NABH and NABL Accreditations.
NABH accreditation is proof of highest standard of care and service provided to the patients. NABL accreditation reflects the competency of laboratories and equipment based on some national and international standards.
Test report is available digitally too and received within 24 hours.
Note from Ganesh Diagnostic and Imaging Center
- Early checkups are always better than delayed ones. Safety, precaution & care are depicted in the several health checkups at our center.
- Here, at Ganesh Diagnostic and Imagining Center, we present simple & comprehensive health packages for any kind of testing to ensure the early prescribed treatment to safeguard your health.
- So, visit us at the earliest to ensure good health and to maintain an active immune system.
