COMT Genotyping - Book Test at Low Cost

The COMT cistron/gene provides directions for creating an associated catalyst known as catechol-O-methyltransferase. 2 versions of this catalyst area are made up of the cistron. The longer kind, known as membrane-bound catechol-O-methyltransferase (MB-COMT), is principally created by nerve cells within the brain. alternative tissues, together with the liver, kidneys, and blood, turn out a shorter style of the catalyst known as soluble catechol-O-methyltransferase (S-COMT). This type of catalyst helps manage the degree of bound hormones.

In the brain, catechol-O-methyltransferase helps break down bound chemical messengers known as neurotransmitters. These chemicals conduct signals from one neuron to another. Catechol-O-methyltransferase is especially necessary for a section at the front of the brain known as the anterior cortex which organizes and coordinates info from alternative components of the brain.

Other Names for This cistron

Catechol Methyltransferase

COMT_HUMAN

Useful For

Prediction of response to alkaloid replacement medical care for smoking surcease

Investigation of substance dosing for decreasing Brocadopa metabolism

The analysis used for assessing estrogen metabolism

Method Name

Real-Time enzyme Chain Reaction (PCR) with gene Discrimination Analysis

Specimen Needed

Multiple genotype tests may be performed on one specimen once one extraction.

Clinical Info

Catechol-O-methyltransferase (COMT) is concerned with ith the phase II clinical trial (conjugative) metabolism of catecholamines and catechol medicine, like Intropin, similarly because of the catechol-estrogens. COMT transfers a donor methyl radical from S-adenosylmethionine to acceptor radical teams on catechol structures (aromatic ring structures with section hydroxy-groups). (1) Bioactive hormone metabolites area unit metabolized by COMT in conjunction with enzyme (MAO):

-Norepinephrine is alkyl by COMT forming normetanephrine.

-Epinephrine is alkyl by COMT forming metanephrine.

-Dopamine is reborn to homovanillic acid through the combined action of MAO and COMT.

 Parkinson's patients receiving Brocadopa (L-Dopa) medical care are conjointly prescribed a COMT substance to attenuate the metabolism of dopa by COMT, thereby prolonging dopa action.

COMT is additionally concerned with the inactivation of estrogens. oestradiol may be hydroxylated forming the catechol estrogens 2-hydroxyestradiol and 4-hydroxyestradiol. (2) These hydroxylated estradiols area unit alkyl by COMT, forming the corresponding methoxyestradiol. The cistron coding COMT is transcribed from different promoters to supply a pair of kings of the catalyst, a soluble short style of the catalyst, and a membrane-bound long kind. Variants within the COMT cistron area unit were thus selected within the literature by the position of the amino alkanoic acid amendment in each of the short and long styles of the catalyst. One ester variant (SNV) in coding DNA four of the cistron produces an associate amino alkanoic acid amendment from essential amino acid to essential amino acid (Val108/158Met). The presence of essential amino acid at this position reduces the utmost activity of the variant catalyst by twenty-fifth and conjointly leads to considerably less immunoreactive COMT supermolecule, leading to a 3-fold to 4-fold decrease in activity compared to wild kind (valine at this position). This variant has been related to the prediction of response and risk of reliance victimizedizedn alkaloid replacement medical care for smoking surcease.