DPD/DPYD Mutation Analysis

DPD (dihydropyrimidine dehydrogenase) is an enzyme that plays a crucial role in the metabolism of fluoropyrimidines, a class of chemotherapy drugs used to treat various cancers. DPYD (dihydropyrimidine dehydrogenase gene) is the gene that encodes for the DPD enzyme.

Individuals with certain DPYD mutations may have reduced or absent DPD enzyme activity, leading to increased levels of toxic metabolites in the body when exposed to fluoropyrimidines. This can result in severe adverse effects, including gastrointestinal symptoms, myelosuppression, and neurotoxicity. Therefore, identifying these patients with DPYD mutations can help clinicians to optimize chemotherapy dosing and avoid life-threatening complications.

DPD/DPYD mutation analysis is a test that examines a patient's genetic material for changes (mutations) in the DPYD gene that can affect the function of the DPD enzyme. The test is usually performed before a patient is prescribed fluoropyrimidine-based chemotherapy to identify those who may be at risk of severe or even fatal side effects due to impaired metabolism of the drug.

Why is DPD/DPYD Mutation Analysis Done?

DPD/DPYD mutation analysis is done for several reasons, primarily to identify patients who may be at increased risk of severe or life-threatening side effects when taking fluoropyrimidine-based chemotherapy drugs.

By identifying patients with DPYD mutations, clinicians can optimize chemotherapy dosing and avoid life-threatening complications. This analysis can help to prevent unnecessary toxicity and reduce treatment-related morbidity and mortality.

DPD/DPYD mutation analysis may also be performed in patients with a known history of severe or unexpected side effects from fluoropyrimidine-based chemotherapy or in patients with a family history of DPYD-related adverse reactions.

Sample Type

>>Blood sample
or
>>Saliva Sample

Cost of DPD/DPYD mutation analysis

The cost of DPD/DPYD mutation analysis ranges from INR 5,000 to INR 35,000.