Factor V Leiden Mutation Test Cost & Procedure

Deep vein thrombosis (DVT) and/or venous thromboembolism are conditions where blood clots (thrombus) form in veins for the wrong reasons as a result of the factor-V-Leiden change (VTE). The lab examination is requested to aid in identifying the cause. The two coagulation factors that are essential for healthy blood clot formation are prothrombin and factor V. Blood clots are more likely to form in people who have mutations in one of the genes that codes for these factors.

Requirements for Factor V Leiden Mutation Test:

• You must take certain steps before the test if your doctor suspects factor V Leiden.
• List your health conditions, medications, allergies, and any prior or present medications, as well as any symptoms or recurring changes Anticoagulants

might prevent them from working.

• Before the test, there is no advised special diet. To stay hydrated, consume plenty of water.

Factor V Leiden Mutation Test Applications:

• To diagnose factor V Leiden thrombophilia, a coagulation screening test or DNA analysis of the F5 gene can be employed.
• In Factor V Leiden, the precise G-to-A substitution is referred to. Blood clot risk can increase by up to 80 times in individuals with two copies of the Factor V Leiden mutation, compared to 4–8 times in those with only one copy.

Test for Factor V Leiden Mutation Procedure:

• Two different tests might be chosen depending on the circumstance:
  • Test for activated protein C resistance:
    • A sample of the patient's blood is needed.
    • In the elbow pit's superficial vein, insert a needle.
    • Take a sample and check it for blood's resistance to activated protein C.
    • The presence of activated protein C resistance in your blood indicates a mutation in the factor V gene. When the test for activated protein C resistance cannot be performed, a genetic evaluation is performed.

Limitations of Factor V Leiden Mutation Test

 However, this test does not screen for several genetic and non-genetic variables that may contribute to the higher risk of thrombosis. This test helps identify people who have the factor V R506Q (Leiden) mutation, which increases the risk of thrombosis. LabCorp created this test and determined its performance parameters.