Flow Cytometry For Leucocyte Adhesion Deficiency - Book Test at Low Cost

Flow cytometry is a powerful tool used to analyze cells in a suspension based on their physical and chemical properties. It is commonly used to study the immune system and is often used to diagnose and monitor immune-related disorders such as Leucocyte Adhesion Deficiency (LAD).

Leucocyte Adhesion Deficiency (LAD) is a rare genetic disorder characterized by a defect in the expression or function of integrin molecules on leukocytes, resulting in impaired adhesion and migration of leukocytes to sites of infection or inflammation. This defect leads to recurrent infections, delayed wound healing, and other complications.

Flow cytometry can be used to detect and quantify the expression of integrin molecules on leukocytes. Specifically, flow cytometry can be used to analyze the expression of the CD18 molecule, which is a subunit of integrins. A decrease in CD18 expression is characteristic of LAD and can be used to diagnose the disorder.

In addition to diagnosing LAD, flow cytometry can also be used to monitor the response to treatment and to detect any changes in CD18 expression over time.

Why is Flowcytometry for Leucocyte Adhesion Deficiency done?

Flow cytometry for Leucocyte Adhesion Deficiency (LAD) is done to diagnose the disorder and monitor its progression and response to treatment. LAD is a rare genetic disorder that affects the function of integrin molecules on leukocytes, resulting in impaired adhesion and migration of leukocytes to sites of infection or inflammation. This defect leads to recurrent infections, delayed wound healing, and other complications.

In the case of LAD, flow cytometry is used to detect and quantify the expression of integrin molecules on leukocytes, specifically the CD18 molecule, which is a subunit of integrins. A decrease in CD18 expression is characteristic of LAD and can be used to diagnose the disorder.

In addition to diagnosing LAD, flow cytometry can also be used to monitor the response to treatment and to detect any changes in CD18 expression over time. This allows healthcare professionals to tailor treatment plans to individual patients and optimize their care.

Overall, flow cytometry is an essential tool in the diagnosis and monitoring of LAD and other immune-related disorders.

Sample type for Flowcytometry for Leucocyte Adhesion Deficiency

The sample type for Flowcytometry for Leucocyte Adhesion Deficiency (LAD) is typically a blood sample.

Procedure

To perform flow cytometry for LAD, leukocytes (white blood cells) are isolated from a blood sample and labelled with fluorescent antibodies that bind to CD18. The cells are then passed through a flow cytometer, which detects and measures the fluorescence of the cells as they pass through a laser beam. The data generated by the flow cytometer can be analyzed to determine the level of CD18 expression in the leukocytes.

Cost of Flowcytometry for Leucocyte Adhesion Deficiency

The cost of Flowcytometry for Leucocyte Adhesion Deficiency near me in Delhi ranges from INR 3000  to INR 25000.