IHC - Epithelial Membrane Antigen Test Cost & Procedure

The surface of numerous healthy classes of epithelium, like those in the pancreas, stomach, intestine, salivary gland, respiratory tract, urinary tract, and breast, comprises a class of HMW molecules that are prosperous in carbohydrates but inadequate in protein. This group of molecules is understood as epithelial membrane antigen (EMA), and it is an incompletely depicted antigen.

The membrane of secretory epithelia comprises epithelial membrane antigen (EMA). The antibody marks Reed-Sternberg cells in nodular lymphocyte predominance Hodgkin's lymphoma and neoplastic cells in a subset of anaplastic large cell lymphomas for the classification of hematolymphoid neoplasms.

Clinical Significance

IHC with interpretation for epithelial membrane antigen These CD markers are established on respective hematological cells. On unidentified cells, precise IHC markers can be applied individually or in classes, and the existence or scarcity of the antigen can help in describing the target cell.

What is EMA in immunohistochemistry?

Glycoproteins sheltered from human milk fat globule membranes, designated epithelial membrane antigen (EMA), have been noticed immunohistochemically in most nonneoplastic epithelia and are possibly a highly influential marker for selecting the epithelial disposition of neoplastic cells.

Usage

It serves as a target in immunohistochemistry where it is a common epithelial marker and expressed by many adenocarcinomas with a poor prognosis beyond that it is expressed by meningiomas, Paget disease, epithelioid sarcomas, and synovial sarcomas It also is sometimes seen within the cytoplasm of cells (e.g. perinuclear dot in ependymomas)

IHC manifestation for Ordinary tissues

•  Specified staining of theca externa
• Corpora lutea  and luteomas of pregnancy
• Testicular Sertoli and Leydig cells
• Mammary gland
• Placental trophoblast
• Endometrium, myometrium, and Fallopian pipe are reportedly not immune reactions
• Nonreproductive organs constituting the brain, pituitary, lung, spleen, pancreas, kidney, adrenal, and prostate are all verified immunoreactions.
• Stromal hyperthecosis

Sample Required

Patient Preparation

Compile

Tissue or compartments.

Specimen Preparation

Formalin fix and paraffin-embedded sample. Protection paraffin bloc and drops from disproportionate warmth. Transport tissue block or five unstained entirely prosecuted drops in a tissue carrier kit.

Warehouse/Transport Temperature

Chamber temperature or cooled. Export in a cooled receptacle during the summer months.

Inappropriate crises

Samples proposed with non-representative tissue variety. Drained samples.

Remarks

IHC Ordering and Submission Details: A submitted electronic proposal. If you do not have the electronic mandating capacity, use an ARUP IHC Stain Form with an ARUP customer numeral.

Strength

Ambient: unspecified; Chilled: unspecified; Frozen: Indecent

Procedure

IHC

Pseudonyms

Inhibin antibody immunostaining

Inhibin IHC

Clinical

Consideration Interval

Interpretive Data

This examination was formulated and its interpretation traits were specified by ARUP Labs. It has not been emptied or authorized by the US ie. This examination was conducted in a CLIA-certified lab and is planned for clinical objectives.