Immunohistochemistry (IHC) - PMS2 Test Cost & Procedure

What does the gene PMS2 mean?

A gene that codes for proteins is called PMS2 (PMS1 Homolog 2, Mismatch Repair System Component).

What are PMS2 and MLH1?

A two-protein complex known as a dimer is created when the MLH1 protein and PMS2 protein (produced by the PMS2 gene) combine. The actions of additional proteins that correct mistakes generated during DNA replication are coordinated by this complex.

What is Lynch syndrome in PMS2?

Lynch syndrome is a disorder you get if you have a mutation in the PMS2 gene. You are more likely to develop some types of cancer, such as carcinoma of the colon and rectum. Endometrial (uterine) cancer.

A tumor suppressor gene called PMS2?

As a result, PMS2 functions as a tumor suppressor in PCa cells, and this impact is supported by increased proliferation brought on by the silencing of this gene, as seen in PWR-1E cells that are generally healthy.

What is a positive PMS2?

Lynch syndrome, formerly known as hereditary non-polyposis colorectal cancer, affects people with PMS2 mutations (HNPCC). You have a higher risk of getting stomach, ovarian, small intestinal, endometrial/uterine, colorectal, and other cancers.

How dangerous is PMS2?

About 15% of women who have a defective PMS2 gene will get colon cancer in their lifetime. Throughout their lives, women with a defective PMS2 gene had a 15% probability of developing endometrial cancer and a 3% chance of developing ovarian cancer.

What purpose does PMS2 serve?

A protein crucial for mending DNA can be produced thanks to the PMS2 gene. To prepare DNA for cell division, this protein aids in the correction of mistakes made during DNA replication.

How typical is PMS2?

Only 9% of the 3,300 distinct MMR gene variations identified in the International Society for Gastrointestinal Hereditary Tumors (InSiGHT) database are found in PMS2, compared to 39% in MLH1, 33% in MSH2, and roughly 19% in MSH6.

The location of the PMS2 gene.

DNA chromosome 7

The PMS2 gene, also known as PMS1 homolog two or mismatch repair system component, is found on chromosome 7. In repairing DNA damage, the PMS2 gene protein is crucial.

The PMS2 gene's location is unknown.

DNA moThe PMS2 gene encodes DNA repair proteins involved in mismatch repair. The PMS2 gene has 15 exons and is found on chromosome 7p22.

What happens if a Lynch syndrome test is positive?

Even if you test positive for Lynch syndrome, which indicates that genetic abnormalities were discovered in your blood, you may not have cancer. It implies that you have a 60 to 80% lifetime probability of having colon cancer.