Melanoma-P16 Gene Sequencing Test Cost & Procedure

DNA splicing in the p16 gene is discovered using melanoma p16 gene sequencing. This gene serves as a diagnostic for melanosomes because it is lost from numerous tumour cell lines, including melanomas.

Chromosome 9p21, which has been associated with familial melanoma and is homozygously deleted in numerous tumour cell lines, contains the p16 gene.

P16 Gene: What is it?

• p16 is a protein that suppresses the passage of the cell cycle from the G1 phase to the S phase, delaying cell division and acting as a tumour suppressor.
• It is also known as p16INK4a, CDKN2A, multiple tumour suppressor 1, and by many other names.
• The CDKN2A gene produces its protein.

Melanoma:

Insufficient or dysfunctional p16 can speed up the cell cycle and cause a variety of cancers if this gene is deleted (the removal of a portion of the DNA sequence during replication).

• Additionally, melanoma can develop in your eyes and, very rarely, in other places on your body like your neck or nose.
• You can lower your chance of developing melanoma by minimizing your exposure to UV light.

Symptoms:

• The moles
• You can get melanomas anywhere on your body.

Melanomas can form in spots that don't receive a lot of sun exposure, such as the palms of your hands, the bottoms of your feet, and the undersides of your fingernails.

Initial signs and symptoms of melanoma commonly include:

• a change to an already existing mole
• your skin developing a new, pigmented growth or another unusual feature

Moles are not usually the first melanoma symptoms to appear. Even skin that otherwise seems to be normal may experience it.

Procedure:

• The patient's arm will be used to extract the sample from a vein.
• The patient's arm will be punctured with a sterilized needle.
• The blood draw will be about 2ml. A cotton swab will be used to clean the area.
• To determine the DNA sequence, the blood sample will be put through PCR equipment.
• The sequencing will be examined to see if any viral DNA is present.