Plasminogen Activator Inhibitor-1 (Serpine-1) 4G/5G Genotyping Test Cost & Procedure

This test examines genetic conditions in myocardial infarction or venous thromboembolism.

What is Plasminogen Activator Inhibitor-1?

The SERPINE-1 gene encodes it. This is involved in the process of hemostasis.

What is 4G/5G?

This is a polymorphism in the gene of PAI-1

What is Genotyping?

It is a procedure that aids in investigating genetic variations with the help of changes in the DNA.

Acute Myocardial Infarction:

They are commonly known as Heart Attacks. It is a fatal condition in which the blood flow is restricted and causes tissue necrosis.

This occurs due to obstruction in the coronary artery.

Symptoms seen are :

• Pain in chest
• Back pain
• Tightness in chest
• Anxiety
• Nausea
• Sweating
• Vomiting
• Breathlessness
• Fainting
• Tiredness

Causes:

The coronary artery is responsible for transporting oxygen-rich blood to your organs. When there is any blockage in this artery, it results in myocardial infarction with time.

Venous Thromboembolism:

Thrombo: "clot"

Embolism: "Embolism"

Venous: "Veins"

It can result in different conditions:

• Pulmonary embolism
• Deep vein thrombosis.

 When any vein obstruction is seen, the blood collects behind this, and oxygen is not available for cells which causes tissue damage.

This further leads to the blockage of oxygen to the lungs, which is very dangerous.

Symptoms seen are:

• High temperature
• Swelling
• Pain
• Swelling
• Rapid heart rate
• Loss of consciousness
• Sweating
• Shortness of breath
• Rapid breathing
• Hemoptysis

Risk Factors :

• Slow blood flow
• Cancer
• High estrogen
• Injury to vein
• Polycythemia
• Sickle cell disease
• Birth control pills
• Inflammatory bowel disease
• Old age
• Absence of workout

The procedure of the test:

Blood Samples:

For a blood sample :

• The needle is inserted into the arm.
• The required amount of blood is withdrawn.
• Cotton is placed over the site.
• The model is sent for examination.

In the case of the Saliva Sample:

• A piece of Cotton is placed in the oral cavity, and sputum is taken.