Chromosome Analysis (Married Couple) Test Cost and Procedure

Description

This test aids in identifying the chromosomal reasons of foetal death and estimating the likelihood that similar pregnancy losses may occur again. Chromosomal anomalies can cause spontaneous abortions, deformed foetuses, or neonatal mortality. With chromosomal anomalies, spontaneous abortions occur between 15 and 60% of the time.

Methodology

Harvest/Hybridization/Microscopy/Interpretation

Prerequisites for Specimens

Analysis is possible on the placenta, umbilical cord, and internal foetal organs. Please send chorionic villi if at all possible.

Transport media or sterile saline in sterile, leak-proof containers (i.e. Hanks Balanced Salt Solution). Don't submerge in formalin.

Maximum Amount: 1x1x1 cm of at least two foetal tissues, one of them being chorionic villi.

• 1 Foetal tissue is the minimum quantity.
• Maintaining at Room Temperature
• 8 hours of stability at room temperature, then refrigerate
• Avoid freezing or overheating when travelling.

Time to Complete

90% of cases receive their final report in 24–48 hours.

Clinical Results

PIP: Couples having a history of frequent abortions were examined to determine the prevalence of chromosomal abnormalities. 14 couples with a history of two or more spontaneous abortions participated in the study. Using peripheral lymphocyte cultures, chromosome analysis was performed on both spouses. 30-62 metaphases were counted in each case, and at least 20 karyotypes were performed. In one of the 14 couples, a chromosomal aberration was discovered in one of the partners.

The 29-year-old lady, who was carrying her tenth child, was admitted to the hospital in the 36th week of her pregnancy. Her past included seven spontaneous abortions at the first or second month in addition to an induced abortion and an early delivery. Her peripheral blood's chromosome analysis showed neither numerical nor structural aberrations.

A medium-sized, subterminal chromosome with a D/G translocation diagnosis could not be included in any of the categories. The husband was found to carry a balanced D/G translocation. The younger sister of the husband had delivered a child one month early, it was discovered while the pedigree was being created. The sister and her young child were both examined. The sister was a balanced D/G translocation carrier, it was discovered. The D/G translocation in the infant had an imbalanced form, resulting in translocational Down's syndrome.

Cytogenetic testing on both partners is typically acceptable in situations involving repeated abortions. Important information can be gleaned from chromosomal aberration cases to serve as a foundation for genetic counselling. Selecting patients who can potentially receive an intrauterine cytogenetic diagnosis during the examination of women who have had recurrent abortions should be possible..