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A blood test called the KIT-4 gene modification evaluation is used to look for cancers like melanoma, acute myeloid leukemia, GIT stromal tumors, and other tumors. Tumors that develop in the GIT tract are known as GISTs. These are mainly established in the small intestine or the abdomen. Since gastrointestinal cancers are frequently associated with KIT gene modifications or alterations, this test makes it simple to find them.
One of the most effective diagnostics for identifying GISTs is the KIT gene mutation test. It is important to notify your doctor right once if you experience any GIST symptoms, such as stomach pain, loss of appetite, or blood in your stools or vomit. This facilitates early tumour detection and prompt treatment.
To find mutations and identify several diseases, including leukaemia, unilateral ovarian dysgerminoma, and others.
The reaction to anti-epidermal expansion characteristic receptor Ab antidote for metastatic colorectal cancer is defined by the presence of clinically substantial modifications in the KRAS and NRAS genes .
Studying the incidence of clinically significant mutations in the KRAS and NRAS genes that are excluded from FDA-approved qPCR assays was the goal of this investigation.
Formalin-fixed, paraffin-embedded tumour samples from 1113 mCRC were used in the study.
From the samples that were examined for KRAS mutations, 33.69% did. 71.77% of these were in codon 12 and 276.9 percent were in codon 13. (both located in exon 2). For the remaining 0.54%, codons 59 (exon 3) and 146 (exon 4) were responsible. In codon 12 (3.61%) of the 83 specimens examined by NRAS, three mutations were discovered. If an FDA-approved qPCR diagnostic test had been employed, about 6% of RAS mutant specimens would have been mistakenly classified as RAS wild type.
Although these qPCR-based kits can be quite useful and sensitive, their mutation coverage excludes mutations from populations with low genetic characterization.
Test Type | KIT-4 Exons (Rare) |
Includes | KIT- 4 Exons (Rare) Test (Pahology) |
Preparation | |
Reporting | Within 24 hours* |
Test Price |
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