P3NP: Procollagen Type 3 Amino Terminal Peptide Test Cost & Procedure

This test is used for the management of patients with psoriasis. This test is advised to manage the dosage of methotrexate.

What is P3NP(Pro collagen Type 3 Amino Terminal Peptide):

It is a peptide present in the extracellular fluid. Its levels are increased in liver damage and tissue repair.

Why is this test done?

When a patient suffers from a skin condition known as psoriasis.

It is used to analyze the management of liver fibrosis. This is done to monitor the dose of the drug given for liver fibrosis so that it does not cause hepatotoxicity. Methotrexate is the choice of drug for psoriasis.

Therefore, during the treatment of psoriasis, this test is recommended.

What is Liver Fibrosis?

When the liver cells are damaged and scarred, this condition is marked by a decreased liver activity called liver fibrosis. If this persists for a long time, it can also cause liver cirrhosis. Medicines and lifestyle modifications can treat it.

Liver Fibrosis can be staged as follows:

This can detect the Level to which the liver is damaged.

Activity Range:

• A0: no activity seen
• A1: Mild Activity seen
• A2: Moderate Activity seen
• A3: Severe Activity seen

Fibrosis stage:

• F0: No fibrosis
• F1: fibrosis without septa
• F2: Fibrosis with septa
• F3: septa with fibrosis
• F4: Cirrhosis

Histologically Classified as:

• Severe hepatitis
• Mild hepatitis
• Minimal hepatitis

Symptoms of liver damage:

• Nausea
• Weakness
• Weight loss
• Jaundice
• Abdominal upset
• tiredness

Causes:

• Obstruction
• Non-alcoholic fatty liver
• Autoimmune hepatitis

Psoriasis:

It is an autoimmune skin disorder caused by stress or any other infection. Skin rashes and swelling is seen in this disorder.

Variants of psoriasis:

• Plaque psoriasis
• Erythrodermic psoriasis
• Inverse psoriasis
• Pustular psoriasis

Symptoms:

• Itching
• Skin pain
• Joint pain
• Infection

Causes:

• Stress
• Certain medications
• Cuts and scratches

Procedure:

• A blood sample is needed.
• The needle is pricked into the arm.
• The blood is withdrawn.